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. 1993 Aug;202(6):364-370.
doi: 10.1007/BF00188735.

Thrombomodulin distribution during murine development

Virginia A Ford  1 , John E Wilkinson  2 , Stephen J Kennel  3
Affiliations

Thrombomodulin distribution during murine development

Virginia A Ford et al. Rouxs Arch Dev Biol. 1993 Aug.

Abstract

Thrombomodulin is a transmembrane glycoprotein involved in the regulation of clot formation. Previous work has shown that in the adult mouse, thrombomodulin expression is primarily located on the luminal surface of endothelial cells; whereas during development, thrombomodulin has been localized to the placental parietal endoderm, the neuroepithelium, head mesenchyme, lung bud, and atrium of Day 10.5 post coitum embryos. We examined the expression of thrombomodulin in the adult mouse and throughout murine development from Day 7.5 to Day. 18.5 post coitum. The high expression of thrombomodulin in the lung bud, developing gonads, leptomeninges, and the parietal endoderm in comparison to the expression levels in the adult organs suggest that thrombomodulin may play an important role in development.The submitted manuscript has been authored by a contractor of the U.S. Government under contract No. DE-AC05-840R21400. Accordingly, the U.S. Government retains nonexclusive, royalty-free license to publish or reproduce the published form of this contribution, or allow others to do so, for US Government purposes.

Keywords: Angiogenesis; Monoclonal Antibodies; Murine development; Thrombomodulin expression.

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References

    1. Biochemistry. 1977 Dec 27;16(26):5824-31 - PubMed
    1. Blood. 1986 Feb;67(2):362-5 - PubMed
    1. Proc Natl Acad Sci U S A. 1986 Dec;83(23):8834-8 - PubMed
    1. J Biol Chem. 1990 Nov 25;265(33):20156-9 - PubMed
    1. J Biol Chem. 1989 Mar 25;264(9):4872-6 - PubMed