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Comment
. 2017 Mar 16;24(3):250-251.
doi: 10.1016/j.chembiol.2017.03.006.

Mapping New Residents of the Mitochondrial Nucleoid

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Mapping New Residents of the Mitochondrial Nucleoid

Laura Trinkle-Mulcahy. Cell Chem Biol. .
Free article

Abstract

In this issue of Cell Chemical Biology, Han et al. (2017) used a powerful combination of quantitative ratiometric mass spectrometry with APEX peroxidase-catalyzed proximity biotinylation to selectively highlight proteins associated with mitochondrial DNA above the background of contaminants and matrix proteins. In addition to identifying novel nucleoid factors, this study extends the APEX strategy to the proteomic mapping of non-membrane-bound multiprotein complexes.

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