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Comparative Study
. 1987 Dec;31(12):2005-6.
doi: 10.1128/AAC.31.12.2005.

Comparison of fluconazole and amphotericin B in treating histoplasmosis in immunosuppressed mice

G S Kobayashi  1 , S J Travis, G Medoff
Affiliations
Comparative Study

Comparison of fluconazole and amphotericin B in treating histoplasmosis in immunosuppressed mice

G S Kobayashi et al. Antimicrob Agents Chemother. 1987 Dec.

Abstract

Fluconazole (UK-49,858) was compared with amphotericin B in treating histoplasmosis in female AKR mice immunosuppressed with either cyclophosphamide or cortisone. Both drugs protected animals from a lethal challenge with Histoplasma capsulatum, but neither regimen resulted in cures since viable organisms were cultured from spleens of survivors.

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References

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