[cGMP-dependent cyclic nucleotide phosphodiesterase from human lymphoid cells]
[Article in
Russian]
- PMID: 2830912
Item in Clipboard
[cGMP-dependent cyclic nucleotide phosphodiesterase from human lymphoid cells]
[Article in
Russian]
Biokhimiia.
1987 Nov.
Abstract
The kinetic properties of cyclic nucleotide phosphodiesterase isolated from the cytoplasmic fraction of lymphoblastoma QOS cells were studied. It was demonstrated that the enzyme can be activated in the presence of micromolar concentrations of cGMP. The kinetic properties of the enzyme are characterized by the nonlinear dependence of the cAMP hydrolysis rate on the substrate concentration. The curve becomes linear in the presence of cGMP. The molecular mass of phosphodiesterase as determined from gel filtration data is 80,0000 Da.
Similar articles
-
[Kinetic properties and regulation of cyclic nucleotide phosphodiesterases in lymphoid cells].Bioorg Khim. 1987 Sep;13(9):1157-63. Bioorg Khim. 1987. PMID: 2827690 Russian.
-
Aggregation states of cyclic nucleotide phosphodiesterase of murine thymocytes.Cell Biochem Funct. 1986 Jul;4(3):205-11. doi: 10.1002/cbf.290040307. Cell Biochem Funct. 1986. PMID: 3015450
-
Modulation of rat thymocyte proliferative response through the inhibition of different cyclic nucleotide phosphodiesterase isoforms by means of selective inhibitors and cGMP-elevating agents.Mol Pharmacol. 1993 Nov;44(5):1027-35. Mol Pharmacol. 1993. PMID: 8246905
-
[Modern representations of multiple forms of cyclic nucleotide phosphodiesterases in mammalian tissues].Biokhimiia. 1995 Mar;60(3):364-86. Biokhimiia. 1995. PMID: 7734612 Review. Russian.
-
Cyclic nucleotide phosphodiesterase in normal and leukemic human lymphocytes and lymphoblasts.Adv Cyclic Nucleotide Protein Phosphorylation Res. 1984;16:303-24. Adv Cyclic Nucleotide Protein Phosphorylation Res. 1984. PMID: 6202124 Review. No abstract available.