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. 1987 Oct;10(10):595-7.
doi: 10.1248/bpb1978.10.595.

Inhibition of superoxide anion production in guinea pig polymorphonuclear leukocytes by a seleno-organic compound, ebselen

S Ichikawa  1 , K Omura, T Katayama, N Okamura, T Ohtsuka, S Ishibashi, H Masayasu
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Inhibition of superoxide anion production in guinea pig polymorphonuclear leukocytes by a seleno-organic compound, ebselen

S Ichikawa et al. J Pharmacobiodyn. 1987 Oct.

Abstract

Production of superoxide anion (O2-) induced by tetradecanoyl phorbol acetate (TPA) in intact guinea pig polymorphonuclear leukocytes (PMNL) was markedly inhibited by a seleno-organic compound, 2-phenyl-1,2-benzisoselenazol-3(2H)-one (Ebselen), with glutathione peroxidase-like activity. The compound almost completely inhibited O2- production by a particulate fraction prepared from TPA-treated PMNL at a concentration as low as 250 nM.

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