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Comparative Study
. 1988 Apr;62(4):1416-22.
doi: 10.1128/JVI.62.4.1416-1422.1988.

Identification and expression of a human cytomegalovirus glycoprotein with homology to the Epstein-Barr virus BXLF2 product, varicella-zoster virus gpIII, and herpes simplex virus type 1 glycoprotein H

M P Cranage  1 , G L Smith, S E Bell, H Hart, C Brown, A T Bankier, P Tomlinson, B G Barrell, T C Minson
Affiliations
Comparative Study

Identification and expression of a human cytomegalovirus glycoprotein with homology to the Epstein-Barr virus BXLF2 product, varicella-zoster virus gpIII, and herpes simplex virus type 1 glycoprotein H

M P Cranage et al. J Virol. 1988 Apr.

Abstract

An open reading frame with the characteristics of a glycoprotein-coding sequence was identified by nucleotide sequencing of human cytomegalovirus (HCMV) genomic DNA. The predicted amino acid sequence was homologous with glycoprotein H of herpes simplex virus type 1 and the homologous protein of Epstein-Barr virus (BXLF2 gene product) and varicella-zoster virus (gpIII). Recombinant vaccinia viruses that expressed this gene were constructed. A glycoprotein of approximately 86 kilodaltons was immunoprecipitated from cells infected with the recombinant viruses and from HCMV-infected cells with a monoclonal antibody that efficiently neutralized HCMV infectivity. In HCMV-infected MRC5 cells, this glycoprotein was present on nuclear and cytoplasmic membranes, but in recombinant vaccinia virus-infected cells it accumulated predominantly on the nuclear membrane.

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References

    1. Semin Perinatol. 1983 Jan;7(1):31-42 - PubMed
    1. Nature. 1983 Apr 7;302(5908):490-5 - PubMed
    1. Nucleic Acids Res. 1984 Jan 11;12(1 Pt 2):521-38 - PubMed
    1. J Virol. 1984 Mar;49(3):857-64 - PubMed
    1. Proc Natl Acad Sci U S A. 1984 Feb;81(3):876-80 - PubMed

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