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Review
. 2017 Mar;37(3):963-967.
doi: 10.21873/anticanres.11405.

The role of IL-7 in Immunity and Cancer

Jack Lin  1 , Ziwen Zhu  2 , Huaping Xiao  1   3 , Mark R Wakefield  2 , Vivi A Ding  1 , Qian Bai  2 , Yujiang Fang  4   2
Affiliations
Review

The role of IL-7 in Immunity and Cancer

Jack Lin et al. Anticancer Res. 2017 Mar.

Abstract

Interleukin-7 (IL-7) is a cytokine that has been known since long in immunology, mainly regarding its effects on T-cells and B-cells. IL-7 has been demonstrated to be necessary for both B-cell and T-cell proliferation and lack of IL-7 causes immature immune cell arrest. Interestingly, in recent years, certain studies have strongly suggested that the role of IL-7 is far beyond the field of immunology, it might have direct or indirect effect on cancer. This review aims to summarize the role of IL-7 in immunity and its role in the pathogenesis of neoplasia.

Keywords: IL-7; immunity cancer; review.

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