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Case Reports
. 1988 Mar;45(3):653-6.
doi: 10.1097/00007890-198803000-00031.

Transmission of fatal herpes simplex infection through renal transplantation

B Koneru  1 , A G Tzakis, L E DePuydt, A J Demetris, J A Armstrong, J S Dummer, T E Starzl
Affiliations
Case Reports

Transmission of fatal herpes simplex infection through renal transplantation

B Koneru et al. Transplantation. 1988 Mar.
No abstract available

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Figures

Figure 1
Figure 1
Microscopic section of liver, showing extensive hemorrhagic necrosis (H&E; X200). Intranuclear inclusions typical of herpes simplex were recognized in the sparse remaining viable parenchyma (insert 1A, H&E; 500X) at the edge of necrotic areas. Electron micrographs revealed viral particles characteristic of the herpes simplex group (insert 1B, uranyl acetate and lead citrate, 46,100X).
Figure 2
Figure 2
(a and b) Restriction endonuclease profiles of DNA from standard HSV strains and isolates from 2 kidney transplant recipients. The laboratory strains are HSV-1 (strain F) and HSV-2 (strain G); the clinical isolates are denoted by patient (1 or 2), site of isolation (urine [UR], buffy coat [BC], throat swab [TS], and liver [LV]) and specimen number. The restriction endonucleases used are listed above each gel. The arrows refer to restriction fragments that differentiate patients’ DNA from standard strains.
See this image and copyright information in PMC

References

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    1. Ho M. Virus infections after transplantation in man. Arch Virol. 1977;55:1. - PubMed
    1. Naraqi S, Jackson GG, Jonasson O, Yamashiroya HM. Prospective study of prevalence, incidence, and source of herpes virus infections in patients with renal allografts. J Infect Dis. 1977;136:531. - PubMed
    1. Elliott WC, Houghton DC, Bryant RE, Wicklund R, Barry JM, Bennett WM. Herpes simplex type 1 hepatitis in renal transplantation. Arch Intern Med. 1980;140:1656. - PubMed
    1. Taylor RH, Saul SH, Dowling JN, Hakala TR, Peel RL, Ho M. Primary disseminated herpes simplex infection with fulminant hepatitis following renal transplantation. Arch Intern Med. 1981;141:1519. - PubMed

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