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. 2015;8(Spec Iss 3):72-76.

A study of the influence of dexamethasone on lipid profile and enzyme lactate dehydrogenase

A Arab Dolatabadi  1 , M Mahboubi  2
Affiliations

A study of the influence of dexamethasone on lipid profile and enzyme lactate dehydrogenase

A Arab Dolatabadi et al. J Med Life. 2015.

Abstract

Dexamethasone is an exceptionally applied glucocorticoid unfortunately prescribed too much. This drug is attached to its receptors in the cytoplasm by going through the cell layer, and opens the cell nucleus by the drug-receptor system, being ultimately responsible for systematic effects of corticosteroids. This study was conducted to explore the influence of dexamethasone on serum level of some biochemical parameters in adult men rats. 40 adult male rats were put into 4 test and check collections. The test collection only received saline and the experimental group received dexamethasone of 0.4, 0.7, and 1 mg/ kg doses daily in the form of intraperitoneal inoculation of 1 mL/ day. After serum separation, the serum value of cholesterol, triglycerides (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL) and lactate dehydrogenase were measured and the outcomes were examined by using SPSS and Dunnett software. The test of lipid profile and lactate dehydrogenase was done by using the biochemistry tools and the collections were examined. In this research, meaningful differences in the application of the above hormones were not observed up to 0.7 mg/ kg dose. However, important differences were seen in higher doses i.e. 1mg/ kg in the test collection associated with the administration group (P<0.05). The final result was that the injection of dexamethasone followed in the development of cholesterol and adverse lipid and it could cause tissue damage by increasing lactate dehydrogenase.

Keywords: dexamethasone; lactate dehydrogenase; lipid profile; rat.

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Figures

Fig. 1
Fig. 1
Comparison of the average of serum’s lactate dehydrogenase in the experimental groups
Fig. 2
Fig. 2
Comparison of the mean of the serum’s cholesterol in the experimental groups
Fig. 3
Fig. 3
Comparison of the mean of the serum’s HDL in the experimental groups
Fig. 4
Fig. 4
Comparison of the mean of the serum’s triglyceride in the experimental groups
Fig. 5
Fig. 5
Comparison of the mean of the serum’s LDL in the test collections
See this image and copyright information in PMC

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