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Case Reports
. 2017 Feb 20:20:184-187.
doi: 10.1016/j.rmcr.2017.02.005. eCollection 2017.

Cytomegalovirus pneumonitis complicated by a central peribronchial pattern of organising pneumonia

Maria M Cuadrado  1 , Asia Ahmed  2 , Ben Carpenter  1 , Jeremy S Brown  3
Affiliations
Case Reports

Cytomegalovirus pneumonitis complicated by a central peribronchial pattern of organising pneumonia

Maria M Cuadrado et al. Respir Med Case Rep. .

Abstract

We present five cases of cytomegalovirus (CMV) pneumonitis occurring in patients after recent T cell deplete allogeneic stem cell transplantation (AlloHSCT). These cases were complicated by an organising pneumonia (during the recovery period) with a predominantly central peribronchial pattern. All patients presented with evidence of active CMV pneumonitis which was treated successfully with anti-viral therapy but was followed by persistent severe dyspnoea, cough and hypoxia. High resolution computed tomography (HRCT) imaging showed widespread central peribronchial consolidation with traction bronchiectasis. There was a marked clinical and physiological improvement after treatment with systemic corticosteroids. However, in all patients the lung function remained abnormal and in some cases imaging revealed a fibrosing lung disease. These cases represent a previously undescribed central peribronchial pattern of organising pneumonia complicating CMV pneumonitis that can result in chronic lung damage.

Keywords: Allogeneic stem cells transplantation (AlloHSCT); Cytomegalovirus pneumonitis; Organising pneumonia.

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Figures

Fig. 1
Fig. 1
HRCT appearances for cases 1 (A), 2 (B), 3 (C), 4 (D) and 5 (E). The number above each panel refers to how many days after ASCT the HRCT scan was performed.
See this image and copyright information in PMC

References

    1. Moon Jeung Hee, Kim Eun A. Cytomegalovirus pneumonia: high-resolution CT findings in ten non-AIDS immu nocompromised patients. Korean J. Radiol. 2000 Apr-Jun;1(2):73–78. - PMC - PubMed
    1. Franquet Tomás, Kyung S. Thin-section CT findings in 32 immunocompromised patients with cytomegalovirus pneumonia who do not have AIDS. Am. J. Roentgenol. 2003;181:1059–1063. - PubMed
    1. Drakopanagiotakis Fotios, Paschalaki Koralia, Abu-Hijleh Muhanned. FCCP. Cryptogenic and secondary organizing pneumonia: clinical presentation, radiographic findings, treatment response, and prognosis. Chest. 2011;139(4):893–900. - PubMed
    1. H Nakasone, Onizuka M., Suzuki N. Pre-transplant risk factors for cryptogenic organizing pneumonia/bronchiolitis obliterans organizing pneumonia after hematopoietic cell transplantation. Bone Marrow Transpl. 2013 Oct;48(10):1317–1323. - PubMed
    1. Alnimer Yanal, Salah Samer, Abuqayas Bashar, Alrabi Kamal. Azacitidine-induced cryptogenic organizing pneumonia: a case report and review of the literature. J. Med. Case Rep. 2016;10:15. - PMC - PubMed

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