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Comment
. 2017 Apr 15;81(8):e57-e59.
doi: 10.1016/j.biopsych.2017.02.004.

The Nature of Nurture: How Developmental Experiences Program Adult Stress Circuitry

Jennifer B Dwyer  1 , David A Ross  2
Affiliations
Comment

The Nature of Nurture: How Developmental Experiences Program Adult Stress Circuitry

Jennifer B Dwyer et al. Biol Psychiatry. .
No abstract available

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Conflict of interest statement

Disclosures: JBD reports no biomedical financial interests or potential conflicts of interest. DAR is co-chair of the NNCI and reports no other biomedical financial interests or potential conflicts of interest.

Figures

Figure 1
Figure 1
Epigenetic regulation of gene expression. (A) (Top) Methylated DNA prevents docking of the transcription machinery, resulting in low or no gene expression. (Bottom) Non-methylated DNA provides easier access for transcription machinery and facilitates gene expression. (B) (Top) Densely packed chromatin, with DNA wrapped tightly around histones, which are spaced close together; this configuration impedes access resulting in low gene expression. (Bottom) Acetylated (Ac) histones, which promote open, loose chromatin, which is more easily accessed and expressed. Histone deacetylases (HDAC) are enzymes that remove acetyl groups and histone acetyl transferases (HAT) are enzymes that add acetyl groups.
See this image and copyright information in PMC

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References

    1. Szyf M. Epigenetics, a key for unlocking complex CNS disorders? Therapeutic implications. Eur Neuropsychopharmacol. 2015;25:682–702. - PubMed
    1. Silverman MN, Sternberg EM. Glucocorticoid regulation of inflammation and its functional correlates: From HPA axis to glucocorticoid receptor dysfunction. Ann N Y Acad Sci. 2012;1261:55–63. - PMC - PubMed
    1. Laryea G, Muglia L, Arnett M, Muglia LJ. Dissection of glucocorticoid receptor-mediated inhibition of the hypothalamic-pituitary-adrenal axis by gene targeting in mice. Front Neuroendocri-nol. 2015;36:150–164. - PMC - PubMed
    1. Jawahar MC, Murgatroyd C, Harrison EL, Baune BT. Epigenetic alterations following early postnatal stress: A review on novel aetiological mechanisms of common psychiatric disorders. Clin Epigenetics. 2015;7:122. - PMC - PubMed
    1. Londono Tobon A, Diaz Stransky A, Ross DA, Stevens HE. Effects of maternal prenatal stress: Mechanisms, implications, and novel therapeutic interventions. Biol Psychiatry. 2016;80:e85–e87. - PMC - PubMed

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