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Review
. 2017 May;17(5):295-305.
doi: 10.1038/nri.2017.12. Epub 2017 Mar 20.

Generation of diversity in thymic epithelial cells

Yousuke Takahama  1 , Izumi Ohigashi  1 , Song Baik  2 , Graham Anderson  2
Affiliations
Free article
Review

Generation of diversity in thymic epithelial cells

Yousuke Takahama et al. Nat Rev Immunol. 2017 May.
Free article

Abstract

In the thymus, diverse populations of thymic epithelial cells (TECs), including cortical and medullary TECs and their subpopulations, have distinct roles in coordinating the development and repertoire selection of functionally competent and self-tolerant T cells. Here, we review the expanding diversity in TEC subpopulations in relation to their functions in T cell development and selection as well as their origins and development.

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