HbA1c in relation to incident diabetes and diabetes-related complications in non-diabetic adults at baseline

Abstract

Aims: We compared the utility of glycated hemoglobin (HbA_1c) and oral glucose tolerance (oGTT) in non-diabetic patients for identifying incident diabetes; all-cause mortality; cardiovascular disease (CVD) mortality; CVD, coronary heart disease (CHD), and ischemic stroke events; and diabetes microvascular complications.

Methods: Data from a New Zealand community setting were prospectively linked to hospitalization, mortality, pharmaceutical and laboratory test results data. After applying exclusion criteria (prior laboratory diagnosis or history of drug treatment for diabetes or hospitalization for diabetes or CVD event), there were 31,148 adults who had an HbA_1c and 2-h 75g oGTT. HbA_1c was measured by ion-exchange high-performance liquid chromatography, and glucose using a commercial enzymatic method. We compared glycemic measures and outcomes using multivariable Cox proportional hazards regression.

Results: The median follow-up time was 4years (range 0 to 13). The mean age was 57·6years and 53·0% were male. After adjusting for other glycemic measures (fasting glucose, 2-h glucose and/or HbA_1c where relevant) in addition to age, sex, ethnicity and smoking habit, the hazard ratios for incident diabetes and diabetes complications of retinopathy and nephropathy were highest for 2-h glucose levels, followed by HbA_1c and lastly by fasting glucose. However, all-cause mortality and CHD were significantly associated with HbA_1c concentrations only, and ischemic stroke and CVD events with 2-h glucose only. Circulatory complications showed a stronger association with HbA_1c.

Conclusion: Apart from neuropathy, HbA_1c showed stronger associations with outcomes compared to fasting glucose and provides a convenient alternative to an oGTT.

Keywords: Cardiovascular disease; Glycated hemoglobin; Incident diabetes; Nephropathy; Neuropathy; Retinopathy.