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. 2017 Jun 1;65(6):593-597.
doi: 10.1248/cpb.c17-00129. Epub 2017 Mar 18.

Cytotoxic Steroids from the Vietnamese Soft Coral Sinularia leptoclados

Ninh Thi Ngoc  1   2 , Tran Thi Hong Hanh  1 , Nguyen Van Thanh  1 , Do Thi Thao  3 , Nguyen Xuan Cuong  1   2 , Nguyen Hoai Nam  1   2 , Do Cong Thung  4 , Phan Van Kiem  1 , Chau Van Minh  1
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Free article

Cytotoxic Steroids from the Vietnamese Soft Coral Sinularia leptoclados

Ninh Thi Ngoc et al. Chem Pharm Bull (Tokyo). .
Free article

Abstract

Fifteen steroids, including two new compounds, leptosteroid (1) and 5,6β-epoxygorgosterol (2), were isolated and structurally elucidated from the Vietnamese soft coral Sinularia leptoclados. Their cytotoxic effect against a panel of eight human cancer cell lines was evaluated using sulforhodamine B (SRB) method. Significant cytotoxicity against hepatoma cancer (HepG2, IC50=21.13±0.70 µM) and colon adenocarcinoma (SW480, IC50=28.65±1.53 µM) cell lines were observed for 1 and against acute leukemia (HL-60, IC50=20.53±2.26 µM) and SW480 (IC50=26.61±1.59 µM) for ergost-5-en-3β,7β-diol (8). In addition, 3β,7β-dihydroxyergosta-5,24(28)-diene (13) showed significant cytotoxic activity on all tested cell lines with IC50 values ranging from 13.45±1.81 to 29.01±3.21 µM.

Keywords: Alcyoniidae; Sinularia leptoclados; cytotoxic activity; soft coral; steroid.

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