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. 1988;96(2):102-6.
doi: 10.1007/BF00331041.

In situ nick translation distinguishes between C-band positive regions on mouse chromosomes

S Adolph  1
Affiliations

In situ nick translation distinguishes between C-band positive regions on mouse chromosomes

S Adolph. Chromosoma. 1988.

Abstract

In situ nick translation of mouse metaphase chromosomes by non-radioactive detection means and DNase I digestion followed by Giemsa staining were used to analyse the DNase I resistance of two different C-band positive regions. These were the centromeric heterochromatin of acro- and metacentric chromosomes and an interstitial C-band on chromosome 1 of wild mice, IS(HSR;1C5D)1Lub. Whereas the centromeric heterochromatin was clearly resistant to DNase I, the interstitial C-band showed very high DNase I sensitivity. Among centromeric C-bands, the heterochromatin in Robertsonian fusion biarmed chromosomes was more resistant to DNase I action than was the centromeric heterochromatin of the acrocentric chromosomes.

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