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Case Reports
. 2017 Jul;27(7):774-775.
doi: 10.1111/pan.13141. Epub 2017 Mar 21.

Anaphylactic reaction to tranexamic acid in an adolescent undergoing posterior spinal fusion

Jennifer Chiem  1 , Iskra Ivanova  1 , Andrew Parker  2 , Walter Krengel 3rd  3 , Nathalia Jimenez  1
Affiliations
Case Reports

Anaphylactic reaction to tranexamic acid in an adolescent undergoing posterior spinal fusion

Jennifer Chiem et al. Paediatr Anaesth. 2017 Jul.

Abstract

Tranexamic acid is an anti-fibrinolytic agent frequently used in pediatric surgery. Common side effects include nausea, flushing, and headache, but in rare instances, it may produce anaphylaxis; with only one previously reported case in a 72-year-old man. We report a case of a delayed anaphylactic reaction in a pediatric patient undergoing posterior spine fusion; and discuss the intraoperative management of the acute event, immunologic confirmation, and subsequent anesthetic approach.

Keywords: anaphylaxis; antifibrinolytic agents; pediatrics; scoliosis; spinal fusion; tranexamic acid.

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