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. 1987 Dec;22(6):698-702.
doi: 10.1007/BF02776741.

Localization of radiolabeled monoclonal antibody S74 in human scirrhous type gastric cancer xenografts in nude mice

T Yokota  1 , T Takahashi, T Yamaguchi, E Otsuji, K Sawai, S Kitai, K Kitamura, A Noguchi, T Ahn
Affiliations

Localization of radiolabeled monoclonal antibody S74 in human scirrhous type gastric cancer xenografts in nude mice

T Yokota et al. Gastroenterol Jpn. 1987 Dec.

Abstract

A mouse monoclonal antibody (MoAb), S74 against a human scirrhous gastric carcinoma cell line was developed. The radioiodinated antibody bound preferentially in vivo to xenografted tumors rather than to normal tissue, whereas tumor uptake of normal mouse IgG did not occur. Thus this MoAb was able to selectively localize a human tumor in an animal model, and clinically it may enable immunotherapy against scirrhous carcinoma of the stomach.

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