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. 2017 Oct;127(10):2265-2269.
doi: 10.1002/lary.26565. Epub 2017 Mar 21.

Long-term local control rates of patients with adenoid cystic carcinoma of the head and neck managed by surgery and postoperative radiation

Safina Ali  1 , Frank L Palmer  1 , Nora Katabi  2 , Nancy Lee  3 , Jatin P Shah  1 , Snehal G Patel  1 , Ian Ganly  1
Affiliations

Long-term local control rates of patients with adenoid cystic carcinoma of the head and neck managed by surgery and postoperative radiation

Safina Ali et al. Laryngoscope. 2017 Oct.

Abstract

Objectives: To report long-term local control in patients with adenoid cystic cancer (ACC) of the head and neck managed by surgery and identify factors predictive for local failure.

Study design: Single-institution retrospective cohort study.

Methods: Eighty-seven patients who had surgery for ACC between 1985 and 2009 were identified. Patient, tumor, and treatment characteristics were recorded. Local recurrence-free survival (LRFS) was recorded by the Kaplan-Meier method. Predictors of local control were identified.

Results: The median age was 54 years. Seventy-two (83%) patients had perineural invasion, 61 (70%) had close/positive margins, and 58 (67%) had pT 1T2. Fifty-nine (68%) patients had postoperative radiation therapy (PORT). With a median follow-up of 85 months, the 10-year LRFS was 78.7%. There were 14 local recurrences. On multivariable analysis, pathological tumor (T)3T4 stage and no PORT were independent predictors for local failure. Patients with no PORT had a 13-fold increased risk of local failure compared to patients treated with PORT (P = 0.003) after adjusting for stage.

Conclusion: After adjusting for T stage, patients who do not get PORT are more likely to have local recurrence.

Level of evidence: 4. Laryngoscope, 127:2265-2269, 2017.

Keywords: Salivary gland; adenoid cystic carcinoma; local recurrence; radiotherapy.

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Conflict of interest statement

Conflicts of interest: none

Figures

Figure 1
Figure 1
Locoregional recurrence free survival stratified by postoperative radiation.
See this image and copyright information in PMC

References

    1. Barnes LEJ, Reichart P, Sidransky D. World Health Organization Classification of Tumours. IARC Press; 2005. Pathology and Genetics of Head and Neck Tumours.
    1. Bhayani MK, Yener M, El-Naggar A, et al. Prognosis and risk factors for early-stage adenoid cystic carcinoma of the major salivary glands. Cancer. 2012 Jun 1;118(11):2872–2878. - PubMed
    1. Sung MW, Kim KH, Kim JW, et al. Clinicopathologic predictors and impact of distant metastasis from adenoid cystic carcinoma of the head and neck. Archives of otolaryngology--head & neck surgery. 2003 Nov;129(11):1193–1197. - PubMed
    1. Batsakis JG, Luna MA, el-Naggar A. Histopathologic grading of salivary gland neoplasms: III. Adenoid cystic carcinomas. The Annals of otology, rhinology, and laryngology. 1990 Dec;99(12):1007–1009. - PubMed
    1. Kim KH, Sung MW, Chung PS, Rhee CS, Park CI, Kim WH. Adenoid cystic carcinoma of the head and neck. Archives of otolaryngology--head & neck surgery. 1994 Jul;120(7):721–726. - PubMed

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