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. 2017 Apr;23(4):699-701.
doi: 10.3201/eid2304.161575.

Significant Decrease in Pertactin-Deficient Bordetella pertussis Isolates, Japan

Yukihiro Hiramatsu, Yusuke Miyaji, Nao Otsuka, Yoshichika Arakawa, Keigo Shibayama, Kazunari Kamachi

Significant Decrease in Pertactin-Deficient Bordetella pertussis Isolates, Japan

Yukihiro Hiramatsu et al. Emerg Infect Dis. 2017 Apr.

Abstract

Prevalence of pertactin-lacking Bordetella pertussis isolates has been observed worldwide. In Japan, however, we found that the frequency of pertactin-deficient isolates in 2014-2016 (8%) was significantly lower than the frequency in 2005-2007 (41%), 2008-2010 (35%), and 2011-2013 (25%). This reduction was closely associated with changes in genotypes.

Keywords: Bordetella pertussis; Japan; bacteria; genotype; multilocus variable-number tandem-repeat analysis; pertactin; pertussis; respiratory infections; whooping cough.

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Figures

Figure
Figure
Temporal trends in the frequency of pertactin-deficient isolates and changes in multi-locus variable-number tandem repeat analysis types (MTs) in the Bordetella pertussis population in Japan. Pertactin production (A) and MTs (B) were analyzed for 232 B. pertussis isolates collected from January 2005 through June 2016. The frequencies of pertactin-deficient isolates and 2 major MTs (MT27 and MT186) are shown by time period. For convenience, minor MTs (MT194, MT224–226, and MT314–316) are included as “others.”
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