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. 1988 Jan;17(1):41-5.
doi: 10.1016/0165-2478(88)90099-5.

Absence of antiviral activity in recombinant B cell stimulatory factor 2 (BSF-2)

T Hirano  1 , T Matsuda, K Hosoi, A Okano, H Matsui, T Kishimoto
Affiliations

Absence of antiviral activity in recombinant B cell stimulatory factor 2 (BSF-2)

T Hirano et al. Immunol Lett. 1988 Jan.

Abstract

Recombinant B cell stimulatory factor 2 (rBSF-2) did not display any detectable level of antiviral activity when using human diploid fibroblasts, DIP-2, FS-4, FS-7, amnion-derived WISH and FL cells with vesicular stomatitis virus (VSV) and Sindbis virus as challenging agents (less than 2.5 X 10(2) IU/mg). Furthermore anti-IFN-beta could not neutralize the immunoglobulin-inducing activity of BSF-2. Moreover anti-BSF-2 could not neutralize the antiviral activity of IFN-beta. The data indicate that BSF-2 is functionally and immunologically not related to IFNs.

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