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. 2018 Jan;10(1):28-42.
doi: 10.1111/1753-0407.12554. Epub 2017 May 29.

Evaluation of antidiabetic activity of biologically synthesized silver nanoparticles using Pouteria sapota in streptozotocin-induced diabetic rats

Sathya Prabhu  1 , Shanmugam Vinodhini  1 , Chakravarthy Elanchezhiyan  2 , Devi Rajeswari  1
Affiliations

Evaluation of antidiabetic activity of biologically synthesized silver nanoparticles using Pouteria sapota in streptozotocin-induced diabetic rats

Sathya Prabhu et al. J Diabetes. 2018 Jan.

Erratum in

  • Erratum.
    [No authors listed] [No authors listed] J Diabetes. 2020 Jan;12(1):95. doi: 10.1111/1753-0407.13002. J Diabetes. 2020. PMID: 31854519 No abstract available.

Retraction in

  • RETRACTION.
    [No authors listed] [No authors listed] J Diabetes. 2021 May;13(5):442. doi: 10.1111/1753-0407.13170. Epub 2021 Mar 24. J Diabetes. 2021. PMID: 40908591 No abstract available.

Abstract

Background: Medicinal plants and green synthesis of silver nanoparticles (AgNPs) have proven to be good sources of agents effective in the treatment of diabetes mellitus. The present study focused on the green synthesis of AgNPs from the aqueous leaf extract of Pouteria sapota in order to evaluate the in vitro and in vivo antidiabetic properties of this extract and the synthesized AgNPs.

Methods: The AgNPs were biologically synthesized under ambient conditions from an aqueous leaf extract of P. sapota using the hot percolation method and were characterized using spectroscopic methods, X-ray diffraction, and scanning electron microscopy. The in vitro antidiabetic activity of the aqueous leaf extract and AgNPs was confirmed by non-enzymatic glycosylation of hemoglobin, glucose uptake by yeast cells following exposure of cells to 5 or 10 mmol/L glucose solution, and inhibition of α-amylase. Further, in vivo antidiabetic activity was assessed in streptozotocin-induced rats. Rats were treated with aqueous leaf extract (100 mg/kg) or AgNPs (10 mg/kg) for 28 days. Following treatment, rats were killed for biochemical and histopathological analysis of kidney and liver samples.

Results: A significant reduction in blood sugar levels was noted in rats treated with leaf extract or AgNPs. Results of in vitro and in vivo analyses in rats treated with leaf extract or AgNPs show that both the extract and the biologically synthesized AgNPs have antidiabetic activity.

Conclusion: The aqueous leaf extract of P. sapota and AgNPs exhibited efficient antidiabetic activity in the rat model of diabetes and therefore could have potential for development for medical applications in the future.

Keywords: Pouteria sapota; antidiabetic; medicinal plants; silver nanoparticles; 山榄果; 药用植物; 银纳米颗粒; 降糖作用.

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