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Review
. 2017 Apr;19(4):34.
doi: 10.1007/s11886-017-0841-2.

Stem Cells in Cardiovascular Medicine: the Road to Regenerative Therapies

Christopher W Anderson  1   2 , Nicole Boardman  1   3 , Jiesi Luo  1   3 , Jinkyu Park  1   3 , Yibing Qyang  4   5   6   7
Affiliations
Review

Stem Cells in Cardiovascular Medicine: the Road to Regenerative Therapies

Christopher W Anderson et al. Curr Cardiol Rep. 2017 Apr.

Abstract

Purpose of review: The purpose of this review is to provide a broad overview of current trends in stem cell research and its applications in cardiovascular medicine. Researches on different stem cell sources, their inherent characteristics, and the limitations they have in medical applications are discussed. Additionally, uses of stem cells for both modeling and treating cardiovascular disease are discussed, taking note of the obstacles these engineered interventions must overcome to be clinically viable.

Recent findings: Tissue engineering aims to replace dysfunctional tissues with engineered constructs. Stem cell technologies have been a great enabling factor in working toward this goal. Many tissue-engineered products are in development that utilize stem cell technology. Although promising, some refinement must be made to these constructs with respect to safety and functionality. A deeper understanding of basic differentiation and tissue developmental mechanisms is required to allow these engineered tissues to be translated into the clinic.

Keywords: Cardiovascular; Embryonic stem cells; Induced pluripotent stem cells; Regenerative medicine; Stem cells; Tissue engineering.

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Conflict of interest statement

Conflict of Interest Christopher W. Anderson, Nicole Boardman, Jiesi Luo, Jinkyu Park, and Yibing Qyang declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Schematic of stem cell applications in cardiovascular medicine. Schematic depiction of iPSCs derived from peripheral blood that are differentiated into a cardiovascular lineage. These cells can be utilized for either tissue engineering constructs to replace dysfunctional vasculature or myocardium for clinical interventions or drug screening in complex, 3D tissues. 2D cell culture also allows for modeling of disease with these cells and high-throughput drug screening
See this image and copyright information in PMC

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