Epithelial Homeostasis: A Piezo of the Puzzle
- PMID: 28324742
- DOI: 10.1016/j.cub.2017.02.002
Epithelial Homeostasis: A Piezo of the Puzzle
Abstract
A recent study shows that, upon stretching or wounding, epithelia display a fast proliferative response that allows for re-establishment of optimal cell density or sealing of the wound. This increased proliferation is induced by the stretch-activated channel Piezo1 and involves calcium-triggered ERK signalling.
Copyright © 2017 Elsevier Ltd. All rights reserved.
Comment on
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Mechanical stretch triggers rapid epithelial cell division through Piezo1.Nature. 2017 Mar 2;543(7643):118-121. doi: 10.1038/nature21407. Epub 2017 Feb 15. Nature. 2017. PMID: 28199303 Free PMC article.
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