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. 2017 Mar 20;27(6):R237-R239.
doi: 10.1016/j.cub.2017.02.001.

Centrosomes: PIDDosome Joins the Counting Game

Susana Godinho  1
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Centrosomes: PIDDosome Joins the Counting Game

Susana Godinho. Curr Biol. .
Free article

Abstract

Centrosome numbers are tightly regulated during the cell cycle. A new study shows that the PIDDosome prevents the propagation of cells carrying amplified centrosomes via p53 stabilisation and p21-mediated cell-cycle arrest, thus ensuring the maintenance of normal centrosome numbers.

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