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. 1988 Apr 6;108(1-2):123-7.
doi: 10.1016/0022-1759(88)90410-3.

Demonstration of high specificity antibodies against phosphatidylserine

L Maneta-Peyret  1 , J J Bessoule, M Geffard, C Cassagne
Affiliations

Demonstration of high specificity antibodies against phosphatidylserine

L Maneta-Peyret et al. J Immunol Methods. .

Abstract

Anti-phosphatidylserine antibodies were raised in rabbits immunized with phosphatidylserine-polyacrylamide gels and with phosphatidylserine-cytochrome c vesicles. A solid-phase immunoenzymatic assay (ELISA) was developed to study the immune serum. The optimal conditions were defined and the technique used to obtain quantitative results. The anti-phosphatidylserine serum diluted to 1/1000 was tested against several phospholipids and was found to be highly specific to phosphatidylserine. This represents the first experimental demonstration of the specificity of antibodies raised against phosphatidylserine.

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