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. 1987 Aug;133(8):2023-9.
doi: 10.1099/00221287-133-8-2023.

Degradation of aflatoxin by Aspergillus flavus

A B Hamid  1 , J E Smith
Affiliations

Degradation of aflatoxin by Aspergillus flavus

A B Hamid et al. J Gen Microbiol. 1987 Aug.

Abstract

Aflatoxin degradative activity was demonstrated in 6- to 12-d-old intact mycelium and cell-free extracts of Aspergillus flavus. The addition of cycloheximide, SKF 525-A or metyrapone to cultures of A. flavus prevented subsequent degradation of the aflatoxins, while in cell-free extracts degradation was inhibited by SKF 525-A, metyrapone and cytochrome c but not by KCN. In cell-free extracts, aflatoxin degradation was enhanced by NADPH and NaIO4. The results suggest the involvement of cytochrome P-450 monooxygenases in the aflatoxin degradative activity of A. flavus.

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