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. 2017 Mar;14(2):205-215.
doi: 10.4306/pi.2017.14.2.205. Epub 2017 Mar 6.

Structural MRI and Amyloid PET Imaging for Prediction of Conversion to Alzheimer's Disease in Patients with Mild Cognitive Impairment: A Meta-Analysis

Eun Hyun Seo  1 , Woon Yeong Park  2 , Il Han Choo  3
Affiliations

Structural MRI and Amyloid PET Imaging for Prediction of Conversion to Alzheimer's Disease in Patients with Mild Cognitive Impairment: A Meta-Analysis

Eun Hyun Seo et al. Psychiatry Investig. 2017 Mar.

Abstract

Objective: The aim of this study was to explore the prognostic values of biomarkers of neurodegeneration as measured by magnetic resonance imaging (MRI) and amyloid burden as measured by amyloid positron emission tomography (PET) in predicting conversion to Alzheimer's disease (AD) in patients with mild cognitive impairment (MCI).

Methods: PubMed and EMBASE databases were searched for structural MRI or amyloid PET imaging studies published between January 2000 and July 2014 that reported conversion to AD in patients with MCI. Means and standard deviations or individual numbers of biomarkers with positive or negative status at baseline and corresponding numbers of patients who had progressed to AD at follow-up were retrieved from each study. The effect size of each biomarker was expressed as Hedges's g.

Results: Twenty-four MRI studies and 8 amyloid PET imaging studies were retrieved. 674 of the 1741 participants (39%) developed AD. The effect size for predicting conversion to AD was 0.770 [95% confidence interval (CI) 0.607-0.934] for across MRI and 1.316 (95% CI 0.920-1.412) for amyloid PET imaging (p<0.001). The effect size was 1.256 (95% CI 0.902-1.609) for entorhinal cortex volume from MRI.

Conclusion: Our study suggests that volumetric MRI measurement may be useful for the early detection of AD.

Keywords: Alzheimer's disease; MRI; Meta-analysis; Mild cognitive impairment.

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Figures

Figure 1
Figure 1. Flow diagram of participant selection for MCI conversion with structural MRI (A) and amyloid PET (B).
Figure 2
Figure 2. Hedges's g of progressive MCI versus stable MCI subjects with clinical follow up (A) Any VOI MRI measurement (B) Amyloid PET (C) Hippocampus volume measurement (D) entorhinal cortex volume measurement. The summary estimates were obtained using a random-effects model. The size of the data markers indicates the weight of the study, which is the inverse of the effect estimate. The diamond data markers indicate the pooled Hedges's g. PHC: parahippocampus cortex, HC: hippocampus, EC: entorhinal cortex, MTC: medial temporal cortex, STG: superior temporal gyrus, GM: gray matter of cerebrum.
See this image and copyright information in PMC

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