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. 2017 Feb;24(1):9-14.
doi: 10.11005/jbm.2017.24.1.9. Epub 2017 Feb 28.

Association between Sarcopenic Obesity and Metabolic Syndrome in Postmenopausal Women: A Cross-sectional Study Based on the Korean National Health and Nutritional Examination Surveys from 2008 to 2011

Sun-Young Kang  1 , Gyeong Eun Lim  1 , Yang Keun Kim  1 , Hye Won Kim  1 , Kayoung Lee  1 , Tae-Jin Park  1 , Jinseung Kim  1
Affiliations

Association between Sarcopenic Obesity and Metabolic Syndrome in Postmenopausal Women: A Cross-sectional Study Based on the Korean National Health and Nutritional Examination Surveys from 2008 to 2011

Sun-Young Kang et al. J Bone Metab. 2017 Feb.

Abstract

Background: Menopause contributes to an increase in visceral fat mass and a decrease in muscle protein synthesis. Therefore, we performed this study to examine their relationship how effect the changes of body composition as obesity and sarcopenia on metabolic syndrome (MS) as a predictor of cardiovascular disease in postmenopausal women.

Methods: Using data from the Korean National Health and Nutrition Examination Survey (KNHANES) from 2008 to 2011, we estimated that 4,183 postmenopausal women underwent dual energy X-ray absorptiometry scans. Sarcopenia was defined as an appendicular skeletal muscle mass divided by body weight that was less than 1 standard deviation below the sex specific mean for the young reference group. After classification into four groups, the results were adjusted with menopausal age and hormonal treatment. The relationship between sarcopenic obesity (SO) and MS in postmenopausal women was analyzed by logistic regression analysis in a complex sampling.

Results: In an unadjusted model, the odds ratio (OR) of MS for sarcopenia was 1.94 (95% confidence interval [CI], 1.52-2.49); the obesity group had an OR of 4.55 (95% CI, 3.63-5.71); and distinctly, the SO group had an OR of 6.26 (95% CI, 5.10-7.70). Even though there was controlling for variable adjustment, no definite difference was seen in the results.

Conclusions: Sarcopenia and obesity were associated with MS independent of other metabolic impairment risk factors in both early menopausal and postmenopausal women. The results showed that, in particular, the prevalence of MS has increased more in postmenopausal women compared with previous research.

Keywords: Menopause; Metabolic syndrome X; Sarcopenia.

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Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1
Fig. 1. Flow chart of subjects selection. KNHNES, Korean National Health and Nutrition Examination Survey.
See this image and copyright information in PMC

References

    1. Lim S, Park KS, Lee HK, et al. Changes in the characteristics of metabolic syndrome in Korea over the period 1998-2001 as determined by Korean National Health and Nutrition Examination Surveys. Diabetes Care. 2005;28:1810–1812. - PubMed
    1. Park E, Choi SJ, Lee HY. The prevalence of metabolic syndrome and related risk factors based on the KNHANES V 2010. J Agric Med Community Health. 2013;38:1–13.
    1. Kim KM, Lim S, Choi SH, et al. Cardiometabolic implication of sarcopenia: the Korea national health and nutrition examination study (KNHANES) 2008-20104. IJC Metab Endocr. 2014:63–69.
    1. Maltais ML, Desroches J, Dionne IJ. Changes in muscle mass and strength after menopause. J Musculoskelet Neuronal Interact. 2009;9:186–197. - PubMed
    1. Kaji H. Interaction between muscle and bone. J Bone Metab. 2014;21:29–40. - PMC - PubMed