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. 1988 Feb;8(2):515-21.
doi: 10.1128/mcb.8.2.515-521.1988.

Swiveling and decatenation of replicating simian virus 40 genomes in vivo

R M Snapka  1 , M A Powelson, J M Strayer
Affiliations

Swiveling and decatenation of replicating simian virus 40 genomes in vivo

R M Snapka et al. Mol Cell Biol. 1988 Feb.

Abstract

We have found that type II topoisomerase inhibitors have two effects on replicating simian virus 40 genomes in vivo: production of catenated dimers and slowed replication of the last 5% of the genome. This suggests that type II topoisomerase simultaneously decatenates and facilitates replication fork movement at this stage of DNA replication. On the basis of this observation, a detailed model is proposed for the roles of topoisomerases I and II in simian virus 40 DNA replication.

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