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. 1979 Mar;62(3):547-54.
doi: 10.1093/jnci/62.3.547.

Karyotypic evolution associated with loss of tumorigenicity

J S Shepard, O S Pettengill, D H Wurster-Hill, G D Sorenson

Karyotypic evolution associated with loss of tumorigenicity

J S Shepard et al. J Natl Cancer Inst. 1979 Mar.

Abstract

A reproducible association between loss of tumorigenicity and specific karyotypic changes was described in cell culture lines SLU-5 and DMS-402 established from mouse plasmacytoma MOPC-21 carried in BALB/c mice. The defect in chromosome no. 15, which has been specifically associated with mouse myelomas, was neither corrected nor eliminated in the karyotypic evolution that occurred simultaneously and progressively with the grandual loss of oncogenicity.

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