doi: 10.1016/0091-3057(88)90266-3.
Milk-induced analgesia and comforting in 10-day-old rats: opioid mediation
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- PMID: 2832857
- DOI: 10.1016/0091-3057(88)90266-3
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Milk-induced analgesia and comforting in 10-day-old rats: opioid mediation
Pharmacol Biochem Behav.
1988 Jan.
Free article
Abstract
The effects of slow intraoral milk infusions on the opioid-mediated behaviors of ultrasonic vocalizations and paw removal from a hot plate (48-49 degrees C) were evaluated in 10-day-old rats. Milk reduced distress vocalization by circa 30% while increasing paw lift latencies by about 60%. Alterations in both behaviors were fully reversed by naltrexone (0.5 mg/kg) pretreatments. These data demonstrate the calming and analgesic effects of milk. Implications for a possible role of opioid peptides in mother-young relationships are discussed.
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