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Randomized Controlled Trial
. 2017 Mar 1;215(5):786-789.
doi: 10.1093/infdis/jix028.

Secretor and Salivary ABO Blood Group Antigen Status Predict Rotavirus Vaccine Take in Infants

Abdul Momin Kazi  1 , Margaret M Cortese  2 , Ying Yu  3 , Benjamin Lopman  2 , Ardythe L Morrow  3 , Jessica A Fleming  4 , Monica M McNeal  5 , A Duncan Steele  4 , Umesh D Parashar  2 , Anita K M Zaidi  1 , Asad Ali  1
Affiliations
Randomized Controlled Trial

Secretor and Salivary ABO Blood Group Antigen Status Predict Rotavirus Vaccine Take in Infants

Abdul Momin Kazi et al. J Infect Dis. .

Abstract

Histo-blood group antigens (HBGAs) expressed on enterocytes are proposed receptors for rotaviruses and can be measured in saliva. Among 181 Pakistani infants in a G1P[8] rotavirus vaccine trial who were seronegative at baseline, anti-rotavirus immunoglobulin A seroconversion rates after 3 vaccine doses differed significantly by salivary HBGA phenotype, with the lowest rate (19%) among infants who were nonsecretors (ie, who did not express the carbohydrate synthesized by FUT2), an intermediate rate (30%) among secretors with non-blood group O, and the highest rate (51%) among secretors with O blood group. Differences in HBGA expression may be responsible for some of the discrepancy in the level of protection detected for the current rotavirus vaccines in low-income versus high-income settings.

Keywords: FUT2; Lewis antigen.; Secretor; blood group; infants; rotavirus; vaccine.

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