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. 2017 Jul 14;38(27):2122-2128.
doi: 10.1093/eurheartj/ehx100.

Utilization and in-hospital complications of cardiac resynchronization therapy: trends in the United States from 2003 to 2013

Seyed Mohammadreza Hosseini  1   2 , Kasra Moazzami  1   2 , Guy Rozen  1   2 , Jeena Vaid  1   2 , Ahmed Saleh  1   2 , Kevin E Heist  1   2 , Mark Vangel  3 , Jeremy N Ruskin  1   2
Affiliations

Utilization and in-hospital complications of cardiac resynchronization therapy: trends in the United States from 2003 to 2013

Seyed Mohammadreza Hosseini et al. Eur Heart J. .

Abstract

Aims: Cardiac resynchronization therapy (CRT) device implantation has been shown to reduce morbidity and mortality in selected patients with heart failure. We sought to investigate the utilization and in-hospital complications of cardiac resynchronization therapy defibrillator (CRT-D) and pacemaker (CRT-P) implantations in the United States from 2003 to 2013.

Methods and results: Patients receiving CRT-D or CRT-P were identified in the National Inpatient Sample database (NIS), using the International Classification of Diseases-Ninth Revision-Clinical Modification procedure codes. Annual implantation rates, patient demographics, co-morbidities, in-hospital complications, and length of stay were analysed. From 2003 to 2013, an estimated total of 439 010 (95% CI: 406 723-471 296) inpatient CRT implantations were performed in the U.S. The median age of patients was 72 and 71% were male. Overall, 6.1% had at least one complication. During the study period, comorbidity index and overall complication rate increased (P = 0.002 and P = 0.01, respectively). Mortality and length of stay showed no significant trend. Predictors of complications included: age 65 and older, female sex (OR: 1.19; 95% CI: 1.12-1.27), Deyo-Charlson Comorbidity Index, and elective admission (OR: 0.61; 95% CI: 0.57-0.66).

Conclusion: From 2003 to 2013, the severity of comorbid conditions increased and a rising trend was observed in the rate of periprocedural complications among patients undergoing CRT in the United States. In-hospital mortality and length of stay showed no uniform trend.

Keywords: Cardiac resynchronization therapy; Complication; Defibrillator; Pacemaker.

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Figures

Figure 1
Figure 1
Types and frequencies of complications following CRT implantation. Pulmonary complications were the most common adverse events in CRT recipients.
Figure 2
Figure 2
Overall in-hospital complications by age group. The highest rate of complications occurred in patients ≥80 years of age.
See this image and copyright information in PMC

Comment in

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