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Comment
. 2017 Mar 21;46(3):344-346.
doi: 10.1016/j.immuni.2017.03.002.

ILC-poiesis: Making Tissue ILCs from Blood

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Comment

ILC-poiesis: Making Tissue ILCs from Blood

Jenny Mjösberg et al. Immunity. .
Free article

Abstract

The development of human innate lymphoid cells (ILCs) remains poorly characterized. In a recent issue of Cell, Lim et al. show that human peripheral-blood CD117+ ILCs harbor ILC precursors (ILCPs) derived from hematopoietic stem cells. Peripheral-blood ILCPs can generate all ILC subsets in vivo and in vitro.

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  • Systemic Human ILC Precursors Provide a Substrate for Tissue ILC Differentiation.
    Lim AI, Li Y, Lopez-Lastra S, Stadhouders R, Paul F, Casrouge A, Serafini N, Puel A, Bustamante J, Surace L, Masse-Ranson G, David E, Strick-Marchand H, Le Bourhis L, Cocchi R, Topazio D, Graziano P, Muscarella LA, Rogge L, Norel X, Sallenave JM, Allez M, Graf T, Hendriks RW, Casanova JL, Amit I, Yssel H, Di Santo JP. Lim AI, et al. Cell. 2017 Mar 9;168(6):1086-1100.e10. doi: 10.1016/j.cell.2017.02.021. Cell. 2017. PMID: 28283063

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