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. 2017 Aug 1;72(8):1137-1142.
doi: 10.1093/gerona/glw197.

Circulating Estrogen Levels and Self-Reported Health and Mobility Limitation in Community-Dwelling Men of the Framingham Heart Study

Guneet Kaur Jasuja  1   2 , Thomas G Travison  3   4 , Joanne M Murabito  5   6 , Maithili N Davda  7 , Adam J Rose  6 , Shehzad Basaria  7 , Andrea Coviello  8 , Ramachandran S Vasan  2   5   8 , Ralph D'Agostino  5   9 , Shalender Bhasin  7
Affiliations

Circulating Estrogen Levels and Self-Reported Health and Mobility Limitation in Community-Dwelling Men of the Framingham Heart Study

Guneet Kaur Jasuja et al. J Gerontol A Biol Sci Med Sci. .

Abstract

Background: Self-rated health is a commonly used global indicator of health status. Few studies have examined the association of self-rated health and mobility with estrone and estradiol in men. Accordingly, we determined the cross-sectional, incident, and mediating relations between circulating estrone and estradiol levels with self-rated health, mobility limitation, and physical performance in community-dwelling men.

Methods: The cross-sectional sample included 1,148 men, who attended Framingham Offspring Study Examinations 7 and 8. Estrone and estradiol levels were measured using liquid chromatography tandem mass spectrometry at Examination 7. Self-reported mobility limitation and self-rated health were assessed at Examinations 7 and 8. Additionally, short physical performance battery, usual walking speed, and grip strength were assessed at Examination 7.

Results: In incident analysis, estradiol levels at Examination 7 were associated with increased odds of fair or poor self-rated health at Examination 8, after adjusting for age, body mass index, comorbidities, and testosterone levels; in an individual with 50% greater estradiol than other, the odds of reporting "fair or poor" self-rated health increased by 1.78 (95% confidence interval: 1.25-2.55; p = .001). Neither estrone nor estradiol levels were associated with any physical performance measure at baseline.

Conclusions: Higher circulating levels of estradiol are associated with increased risk of incident fair/poor self-rated health in community-dwelling men. The mechanisms by which circulating levels of estradiol are related to self-rated health in men need further investigation.

Keywords: Estradiol; Estrone; Physical function; Self-rated health.

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Figures

Figure 1.
Figure 1.
Association between circulating total estrone and estradiol levels, and incident mobility limitation and self-rated health for male Framingham Offspring Study participants (age range: 30–80 years) over 6.6 years. Estimated odds ratios (point estimates and 95% confidence intervals are shown) quantify association between a 50% positive difference in estrone or estradiol and increase in the incidence of mobility limitation, “good,” and “fair or poor” self-rated health. Adjusted models control for age, smoking, body mass index, comorbidities (cancer and/or cardiovascular disease), and total testosterone (for estradiol only). “Excellent” self-reported health was the reference group in these models.
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References

    1. DeSalvo KB, Bloser N, Reynolds K, He J, Muntner P. Mortality prediction with a single general self-rated health question: a meta-analysis. J Gen Intern Med. 2006;21:267–275. doi:10.1111/j.1525-1497.2005.00291.x - PMC - PubMed
    1. Andersen FK, Christensen K, Frederiksen H. Self-rated health and age: a cross-sectional and longitudinal study of 11,000 Danes aged 45–102. Scand J Public Health. 2007;35:164–171. doi:10.1080/14034940600975674 - PubMed
    1. Payette H, Gueye NR, Gaudreau P, Morais JA, Shatenstein B, Gray-Donald K. Trajectories of physical function decline and psychological functioning: the Quebec longitudinal study on nutrition and successful aging (NuAge). J Gerontol B Psychol Sci Soc Sci. 2011;66(suppl 1):i82–i90. doi:10.1093/geronb/gbq085 - PubMed
    1. Schaap LA, Pluijm SM, Smit JH, et al. The association of sex hormone levels with poor mobility, low muscle strength and incidence of falls among older men and women. Clin Endocrinol. 2005;63:152–160. doi:10.1111/j.1365-2265.2005.02315.x - PubMed
    1. Araujo AB, Travison TG, Bhasin S, et al. Association between testosterone and estradiol and age-related decline in physical function in a diverse sample of men. J Am Geriatr Soc. 2008;56:2000–2008. doi:10.1111/j.1532-5415.2008.01965.x - PMC - PubMed