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Comment
. 2017 Mar 22;37(12):3106-3108.
doi: 10.1523/JNEUROSCI.0127-17.2017.

Gpr126 Is Critical for Schwann Cell Function during Peripheral Nerve Regeneration

Corey Fernandez  1 , Manasi Iyer  2 , Isabel Low  2
Affiliations
Comment

Gpr126 Is Critical for Schwann Cell Function during Peripheral Nerve Regeneration

Corey Fernandez et al. J Neurosci. .
No abstract available

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Figures

Figure 1.
Figure 1.
Schematic timeline of axon injury and regeneration. A, Crush or cut injury to axon (red scissors). B, Myelinating SCs are reprogrammed to repair SCs via downregulation of myelin genes and upregulation of repair genes that promote axon elongation and survival. C, Activation of innate immune response: SCs upregulate cytokines to recruit macrophages (orange). Both macrophages and SCs phagocytose myelin debris. D, Büngner band formation guides regrowing axon to target tissue. Contact with axon signals SCs to revert to myelinating SCs. E, SCs remyelinate axon, which reinnervates target tissue. Gray represents neurons. Blue represents myelinating mature SCs. Cyan represents repair SCs.
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