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. 2017 Winter;10(1):54-59.

Evaluation of prognostic factors effect on survival time in patients with colorectal cancer, based on Weibull Competing-Risks Model

Soraya Moamer  1 , Ahmadreza Baghestani  2 , Mohamad Amin Pourhoseingholi  3 , Nastaran Hajizadeh  1 , Farzaneh Ahmadi  1 , Mohsen Norouzinia  4
Affiliations

Evaluation of prognostic factors effect on survival time in patients with colorectal cancer, based on Weibull Competing-Risks Model

Soraya Moamer et al. Gastroenterol Hepatol Bed Bench. 2017 Winter.

Abstract

Aim: The aim of this study was to assess the association between survival of patients with colorectal cancer and prognostic factors in a competing risk parametric model using Weibull distribution.

Background: The prognosis of colorectal cancer is relatively good in terms of survival time. In many prognostic studies, patients may be exposed to several types of competing events. These different causes of death are called competing risks.

Methods: Data was recorded from 372 patients with colorectal cancer who registered in the Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences (Tehran, Iran) from 2004 to 2015 in a retrospective study. Analysis was performed using competing risks model and Weibull distribution. Software used for data analysis was R, and significance level was regarded as 0.05.

Results: The result indicated that, at the end of follow-up, 111 (29.8%) deaths were from colorectal cancer and 14 (3.8%) deaths were due to other diseases. The average body mass index (BMI) was 24.61(SD 3.98). The mean survival time for a patient in 372 was 62.05(SD 48.78) month with median equals to 48 months. According to competing-risks method, only stageIII (HR, 1.69; 95% CI, 1.246-2.315 ), stageIV( HR, 4.51; 95% CI,2.91-6.99 ) and BMI( HR, 0.96; 95% CI, 0.96-0.975) have a significant effect on patient's survival time.

Conclusion: This study indicated pathologic stage (III,IV) and BMI as the prognosis, using a Weibull model with competing risks analysis, while other models without the competing events lead to significant predictors which may be due to over-estimation.

Keywords: Colorectal cancer; Competing risks; Survival analysis; Weibull model.

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Figures

Figure 1
Figure 1
Flowchart of 372 colorectal cancer patients
Figure2
Figure2
Negative Log of Negative Log Survivor Function Estimates.
Figure 3
Figure 3
Estimated survival curves for stage I, stage II, stage III and stage IV patients with colorectal cancer based on a Weibull Competing risk model
See this image and copyright information in PMC

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References

    1. Dolatkhah R, Hossein Somi M, Jabbarpour Bonyadi M, Asvadi Kermani I, Farassati F, Dastgiri S. Colorectal cancer in Iran: Molecular epidemiology and screening strategies. J Cancer Epidemiol. 2015;2015:643020. - PMC - PubMed
    1. Li C, Lu HJ, Na FF, Deng L, Xue JX, Wang JW, et al. Prognostic role of hypoxic inducible factor expression in non-small cell lung cancer: a meta-analysis. Asian Pac J Cancer Prev. 2013;14:3607–12. - PubMed
    1. American Cancer Society. Cancer Facts & Figures 2015. Atlanta: American Cancer Society; 2015.
    1. Azeem S, Gillani SW, Siddiqui A, Jandrajupalli SB, Poh V, Syed SS. Diet and colorectal cancer risk in Asia--A systematic review. Asian Pac J Cancer Prev. 2015;16:5389–96. - PubMed
    1. Alwan A. Global status report on noncommunicable diseases 2010. World Health Organization; 2011. Available from: http://www.who.int/nmh/publications/ncd_report2010/en/

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