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. 2016 Jul 1;12(3):119-122.
doi: 10.5152/tjbh.2016.2961. eCollection 2016 Jul.

The Relationship between Bone Mineral Density and Estrogen Receptor Positivity in Patients with Breast Cancer

Zeynep Erdoğan İyigün  1 , Kezban Nur Pilancı  1 , Fatmagül Kuşku Çabuk  1 , Serkan İlgün  1 , Çetin Ordu  1 , Tomris Duymaz  1 , Gül Alço  1 , Filiz Çelebi  1 , Dauren Sarsenov  1 , Filiz İzci  1 , Alper Öztürk  1 , Filiz Ağaçayak  1 , Ülkühan İner Köksal  1 , Fatma Aktepe  1 , Yeşim Eralp  1 , Vahit Özmen  1
Affiliations

The Relationship between Bone Mineral Density and Estrogen Receptor Positivity in Patients with Breast Cancer

Zeynep Erdoğan İyigün et al. J Breast Health. .

Abstract

Objective: The effect of estrogen on bone mineral density (BMD) and breast cancer has been known for a long time. The aim of this study was to compare of the BMD of patients with breast cancer and healthy individuals, and to investigate the degree of correlation of estrogen receptor (ER) with BMD.

Materials and methods: Seventy-one patients with postmenopausal breast cancer and 79 healthy dividuals were included in the study. The patient demographics (age, menopause age, body mass index, number of children, BMD, Z scores, and estrogen status for breast cancer patients) were taken from hospital records.

Results: No significant difference was detected between the case and control groups in lumbar region Z scores (p=0.074). At the femur neck, the control group Z scores was higher than patient group (p=0.002). BMI was higher in the patients with breast cancer (p=0.001). There was no statistically significant correlation between ER positivity, BMD, and BMI in ER-positive patients (p=0.495, p=0.8, p=0.846, respectively). There was no difference between the Z scores when the patients were divided into two groups as ER positive and negative (p=0.156, p=0.335, respectively).

Conclusion: This study revealed that there is no difference in lumbar region Z scores between patients with breast cancer and heathy controls; however, the Z scores were higher in the femur neck in the control group, and the BMI was lower in the patient group. Tumor ER positivity does not positively affect BMD.

Keywords: Breast cancer; body mass index; bone mineral density; estrogen receptor.

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Conflict of interest statement

Conflict of Interest: No conflict of interest was declared by the authors.

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