Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2016 Nov 23;14(1):52-61.
doi: 10.21010/ajtcam.v14i1.4256. eCollection 2017.

EFFECTS AND MECHANISMS OF A NEW MULTIVITAMIN ON CHRONIC METABOLIC SYNDROMES AND AGING

Su-Xi Wu  1 , Xuewei Jiang  1 , Yu-Ying Liu  2 , Lin-Feng Chen  3 , Jun Tao  1
Affiliations
Randomized Controlled Trial

EFFECTS AND MECHANISMS OF A NEW MULTIVITAMIN ON CHRONIC METABOLIC SYNDROMES AND AGING

Su-Xi Wu et al. Afr J Tradit Complement Altern Med. .

Abstract

Background: Increased occurrence of chronic syndromes has prompted researchers to investigate and develop drugs and methods for controlling chronic syndromes with a view to improve human health and reduce early aging.

Material and methods: Human trials: After the allotted multivitamin pills or placebo pills had been taken for a stipulated period of about 2 months, the volunteers filled out feedback forms on curative effects of the pills in line with the health examination reports. The effects of the multivitamin on various symptoms or diseases and dysfunctions of the chronic metabolic syndromes were noted and evaluated based on the information provided in forms. Animal experiments: Mouse aging model induced by D-galactose were administered the multivitamin by oral gavage every morning. At the end of the sixth week, activity or content of the components associated with ageing and anti-aging in the brain and liver of the aging mice were determined to investigate the mechanisms of the new multivitamin on chronic metabolic syndromes and aging.

Results: We found that multivitamin can eliminate or attenuate 38 types of symptoms or dysfunctions of the investigated metabolic syndromes; and that it has both preventive and curative/adjunctive therapeutic effects on the metabolic syndromes. The effects of this multivitamin on components associated with aging and anti-aging were significantly decreased - malondialdehyde content and monoamine oxidase activity but significantly increased activity of superoxide dismutase and glutathione peroxidase. This multivitamin has significant anti-aging effects.

Conclusion: Supplementing with this multivitamin can prevent and provide treatment/adjunctive therapy for these chronic metabolic syndromes and delay the aging process. List of AbbreviationsBWbody weight; Cu/Zn-SOD, cuprum/zinc-superoxide dismutaseMAOmonoamine oxidaseMDAmalondialdehyde; Mn-SOD, manganese-superoxide dismutase; T-SOD, total superoxide dismutase; TP, total protein.

Keywords: Aging; Anti-aging; Mechanism; Metabolic syndrome; Multivitamin.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest: The authors have no conflicts of interest to declare.

References

    1. Arner P, Bernard S, Salehpour M. Dynamics of human adipose lipid turnover in health and metabolic disease. Nature. 2011;478:110–113. - PMC - PubMed
    1. Bard J G. Genetics of aging: implications for drug discovery and development. Am. J. Clin. Nutr. 2006;83(suppl):466–469. - PubMed
    1. Bensinger J S, Tontonoz P. Integration of metabolism and inflammation by lipid-activated nuclear receptors. Nature. 2008;454:470–477. - PubMed
    1. Bjelakovic G, Nikolova D, Gluud L L, Simonetti R G, Gluud C. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA. 2007;297:842–857. - PubMed
    1. Benedetti S M, Dostert P. Monoamine oxidase, brain ageing and degenerative diseases. Biochem Pharmacol. 1989;38:555–561. - PubMed

Publication types

LinkOut - more resources