Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Mar;49(1):1-9.
doi: 10.3947/ic.2017.49.1.1. Epub 2017 Mar 22.

Molecular Epidemiology of Human Immunodeficiency Virus

Bum Sik Chin  1
Affiliations
Review

Molecular Epidemiology of Human Immunodeficiency Virus

Bum Sik Chin. Infect Chemother. 2017 Mar.

Abstract

During the evolution of human immunodeficiency virus (HIV), transmissions between humans and primates resulted in multiple HIV lineages in humans. This evolution has been rapid, giving rise to a complex classification and allowing for worldwide spread and intermixing of subtypes, which has consequently led to dozens of circulating recombinant forms. In the Republic of Korea, 12,522 cases of HIV infection have been reported between 1985, when AIDS was first identified, and 2015. This review focuses on the evolution of HIV infection worldwide and the molecular epidemiologic characteristics of HIV in Korea.

Keywords: Human immunodeficiency virus; Molecular epidemiology; Phylogeny.

PubMed Disclaimer

Conflict of interest statement

No conflicts of interest.

Figures

Figure 1
Figure 1
Comparison of network analysis (A) and phylogenic tree (B). While the level of interconnection in the cluster is indistinguishable in the phylogenetic tree, network analysis reveals the level of connections. In cluster 4 (red circle), every node is connected with the other nodes while only one node is interconnected with the other two nodes in cluster 16 (blue circle) [74].
Figure 2
Figure 2
Neighbor-joining phylogenetic relationship generated from 2907 HIV-1 subtype B gp120 env sequences. Korean clade B (in red) formed a distinct cluster from worldwide HIV-1 subtype B sequences [66].
See this image and copyright information in PMC

References

    1. Ho DD, Neumann AU, Perelson AS, Chen W, Leonard JM, Markowitz M. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature. 1995;373:123–126. - PubMed
    1. Preston B, Poiesz B, Loeb L. Fidelity of HIV-1 reverse transcriptase. Science. 1988;242:1168–1171. - PubMed
    1. Preston BD, Dougherty JP. Mechanisms of retroviral mutation. Trends Microbiol. 1996;4:16–21. - PubMed
    1. Roberts J, Bebenek K, Kunkel T. The accuracy of reverse transcriptase from HIV-1. Science. 1988;242:1171–1173. - PubMed
    1. Wei X, Ghosh SK, Taylor ME, Johnson VA, Emini EA, Deutsch P, Lifson JD, Bonhoeffer S, Nowak MA, Hahn BH, Saag MS, Shaw GM. Viral dynamics in human immunodeficiency virus type 1 infection. Nature. 1995;373:117–122. - PubMed