Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Jul 15;33(14):2205-2206.
doi: 10.1093/bioinformatics/btx134.

ResistoMap-online visualization of human gut microbiota antibiotic resistome

Konstantin S Yarygin  1   2 , Boris A Kovarsky  2 , Tatyana S Bibikova  3 , Damir S Melnikov  3 , Alexander V Tyakht  1   2 , Dmitry G Alexeev  1   2
Affiliations

ResistoMap-online visualization of human gut microbiota antibiotic resistome

Konstantin S Yarygin et al. Bioinformatics. .

Abstract

Abstract: We created ResistoMap—a Web-based interactive visualization of the presence of genetic determinants conferring resistance to antibiotics, biocides and heavy metals in human gut microbiota. ResistoMap displays the data on more than 1500 published gut metagenomes of world populations including both healthy subjects and patients. Multiparameter display filters allow visual assessment of the associations between the meta-data and proportions of resistome. The geographic map navigation layer allows to state hypotheses regarding the global trends of antibiotic resistance and correlates the gut resistome variations with the national clinical guidelines on antibiotics application.

Availability and implementation: ResistoMap was implemented using AngularJS, CoffeeScript, D3.js and TopoJSON. The tool is publicly available at http://resistomap.rcpcm.org.

Contact: yarygin@phystech.edu.

Supplementary information: Supplementary data are available at Bioinformatics online.

PubMed Disclaimer

References

    1. Clemente J.C. et al. (2015) The microbiome of uncontacted Amerindians. Sci. Adv., 1, e1500183.. - PMC - PubMed
    1. Consortium H.M.P. et al. (2012) Structure, function and diversity of the healthy human microbiome. Nature, 486, 207–214. - PMC - PubMed
    1. Elbehery A.H. et al. (2016) Antibiotic resistome: Improving detection and quantification accuracy for comparative metagenomics. Omics, 20, 229–238. - PubMed
    1. Karlsson F.H. et al. (2013) Gut metagenome in European women with normal, impaired and diabetic glucose control. Nature, 498, 99–103. - PubMed
    1. McArthur A.G. et al. (2013) The comprehensive antibiotic resistance database. Antimicrobial Agents and Chemotherapy, 57, 3348–3357. - PMC - PubMed

Substances