Defining the Impact of Adjuvant Therapy in Molecularly Defined Subsets of Gastrointestinal Stromal Tumor : From Lumping to Splitting
- PMID: 28334361
- PMCID: PMC12180598
- DOI: 10.1001/jamaoncol.2016.5740
Defining the Impact of Adjuvant Therapy in Molecularly Defined Subsets of Gastrointestinal Stromal Tumor : From Lumping to Splitting
Conflict of interest statement
Dr Heinrich is a consultant to MolecularMD, Novartis, Pfizer, and Blueprint Medicines; has received speakers honorarium from Novartis and Pfizer; holds equity interest in MolecularMD (nonpublic); has received research funding from Blueprint Medicines, Deciphera Pharmaceuticals, and Inhibikase; holds intellectual property in the form of a patent licensed to Novartis (royalty to Oregon Health and Science University Knight Cancer Institute); and has provided expert testimony (patent litigation) for Novartis. Dr Demetri is a consultant for Novartis, Pfizer, Daiichi-Sankyo, Blueprint Medicines, Kolltan Pharmaceuticals, and Caris Life Sciences; holds equity interest in Blueprint Medicines (public), Kolltan Pharmaceuticals (private), and Caris Life Sciences (public); has received research funding from Novartis, Bayer, and Pfizer; holds intellectual property in the form of a patent licensed to Novartis (royalty to Dana-Farber Cancer Institute); scientific advisory board member for Blueprint Medicines; and board of directors for Blueprint Medicines. No other disclosures are reported.
Comment on
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Effect of KIT and PDGFRA Mutations on Survival in Patients With Gastrointestinal Stromal Tumors Treated With Adjuvant Imatinib: An Exploratory Analysis of a Randomized Clinical Trial.JAMA Oncol. 2017 May 1;3(5):602-609. doi: 10.1001/jamaoncol.2016.5751. JAMA Oncol. 2017. PMID: 28334365 Free PMC article. Clinical Trial.
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