Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Jan;79(1):17-20.
doi: 10.1111/j.1349-7006.1988.tb00005.x.

Defect in the development of thermotolerance in the mouse temperature-sensitive mutant ts85 lacking ubiquitin-activating enzyme

S Mizuno  1 , A Ohkawara, K Suzuki
Affiliations

Defect in the development of thermotolerance in the mouse temperature-sensitive mutant ts85 lacking ubiquitin-activating enzyme

S Mizuno et al. Jpn J Cancer Res. 1988 Jan.

Abstract

We investigated the effect of heat shock on the development of thermotolerance using mouse FM3A cells and the temperature-sensitive mutant ts85. The shift-up incubation of FM3A from 33 to 39.5 degrees induced thermotolerance to subsequent heating at 44 degrees. In contrast, the similar treatment of ts85 at the nonpermissive temperature of 39.5 degrees could not induce thermotolerance. Furthermore, when ts85 cells were treated at 33 degrees after being heated at 44 degrees, they developed a reduced level of thermotolerance as compared with that developed in FM3A cells. Since ts85 cells are defective in ubiquitin-activating enzyme, these results suggest a role of the ubiquitin-protein conjugation system in the development of thermotolerance.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Hahn , G. M. “ Hyperthermia and Cancer ,” pp . 41 – 53 ( 1982. ). Plenum Press; , New York .
    1. Li , G. C. and Mivechi , N. F.Thermotolerance in mammalian systems; a review . In “ Hyperthermia in Cancer Treatment ,” Vol. I , ed. Anghileri L. J. and Robert J. , pp . 59 – 77 ( 1986. ). CRC Press; , Boca Raton , Florida .
    1. Schlesinger , M. J. , Ashburer , M. and Tissieres , A. “ Heat Shock: From Bacteria to Man ” ( 1982. ). Cold Spring Harbor Lab. , New York .
    1. Arkinson , B. G. and Walden , D. B. “ Changes in Eukaryotic Gene Expression in Response to Environmental Stress ” ( 1985. ). Academic Press; , New York . - PubMed
    1. Landry , J.Heat shock proteins and cell ther‐motolerance . In “ Hyperthermia in Cancer Treatment ,” Vol. I , ed. Anghileri L. J. and Robert J. , pp . 37 – 58 ( 1986. ). CRC Press; , Boca Raton , Florida .

Publication types

LinkOut - more resources