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. 2017 Mar 23;14(1):62.
doi: 10.1186/s12985-017-0708-6.

SVR Rates of HCV-infected population under PEG-IFN-α/R treatment in Northwest China

Yanhua Li  1 , Jiuping Wang  2 , Juan Wang  1 , Yunfeng Xiao  3 , Bin Xu  4 , Hongwei Li  1 , Liu Yang  1 , Xiaoke Hao  5 , Yueyun Ma  6
Affiliations

SVR Rates of HCV-infected population under PEG-IFN-α/R treatment in Northwest China

Yanhua Li et al. Virol J. .

Abstract

Background: Chronic HCV Patients taking PEG-IFN-α/R from different ethnic groups have different probabilities of reaching a sustained viral response (SVR). There are many influence factors, such as HCV genotype, IL-28B single-nucleotide polymorphisms (SNP), Fibrosis 4 index (FIB-4), and aspartate aminotransferase-to-platelet ratio index (APRI) score. But the baseline factors in relation to treatment outcome was still not much clear.

Methods: We evaluated data from 231 chronic HCV patients with or without liver fibrosis and their antiviral efficacy after treatment with pegylated interferon plus ribavirin (PEG-IFN-α/R) for 24-48 weeks. IL-28B SNP and HCV genotypes were analyzed with genome sequencing using pyrosequencing.

Results: Sustained viral response (SVR) rates of patients with HCV 1b and 2a genotypes were 52.25% (58/111) and 75.28% (67/89) (P < 0.01). SVR rates of patients with IL-28B rs8099917 TT, rs12979860 CC and rs12980275 AA were 92.41% (25/27), 92.86% (26/28) and 88.89% (24/27) separately. We found that SVR rates in HCV 1b and 2a patients were only 31.0 and 39.4% if their FIB-4 > 3.25. In addition, when their APRI > 2, only 30.3% of HCV 1b patients and 50.2% of HCV 2a patients could obtain SVR.

Conclusions: There were high proportion of HCV genotype 1b and 2a in Northwest China. In both HCV 1b and 2a genotypes, patients with protective-genotype of IL-28B were more likely to obtain SVR. However, those with significant fibrosis or cirrhosis were less likely, no matter their genotype. Combined factors of HCV genotype, IL-28B genotype, FIB-4 and ARPI may indicate high prediction and clinical value regarding treatment with PEG-IFN-α/R and prognostic evaluation of chronic hepatitis C patients.

Keywords: Chronic hepatitis C; Cirrhosis; HCV subtype; Individualization; Interleukin 28; Single nucleotide polymorphism.

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Figures

Fig. 1
Fig. 1
Distribution of HCV genotype. 86% of the patients with HCV infection were genotype 1 and 2, with 1b accounting for 48.05% and 2a accounting for 38.53%, followed by 1a (5.19%), 3a (4.76%), 3b (2.16%), 2b (0.43%), and 6a (0.43%)
Fig. 2
Fig. 2
a Correlation between HCV genotype distribution and SVR. Sustained viral response (SVR) rates by HCV genotypes 1b and 2a were 52.25% (58/111) and 75.28% (67/89), statistically significant at P < 0.01. Rates of patients with HCV genotype 1b and 2a who did not reach SVR were 70.67 and 29.33%. Relationship between IL-28B genotype and SVR was showed in (b). SVR rates in patients of chronic HCV infection with different IL-28 single-nucleotide polymorphisms (SNP) (rs8099917 TT, rs12979860 CC and rs12980275 AA) were 92.41% (25/27), 92.86% (26/28), and 88.89% (24/27), respectively. In contrast, only 7.41, 7.14 and 11.11% of patients with IL-28B rs8099917 TG + GG, rs12979860 CT + TT, and rs12980275 AG + GG obtained SVR. c showed correlation among IL-28B SNP, HCV genotype and SVR
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