Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Mar 23;16(1):36.
doi: 10.1186/s12938-017-0327-x.

Physical mechanism and modeling of heat generation and transfer in magnetic fluid hyperthermia through Néelian and Brownian relaxation: a review

Suriyanto  1   2   3 , E Y K Ng  4 , S D Kumar  5
Affiliations
Review

Physical mechanism and modeling of heat generation and transfer in magnetic fluid hyperthermia through Néelian and Brownian relaxation: a review

Suriyanto et al. Biomed Eng Online. .

Abstract

Current clinically accepted technologies for cancer treatment still have limitations which lead to the exploration of new therapeutic methods. Since the past few decades, the hyperthermia treatment has attracted the attention of investigators owing to its strong biological rationales in applying hyperthermia as a cancer treatment modality. Advancement of nanotechnology offers a potential new heating method for hyperthermia by using nanoparticles which is termed as magnetic fluid hyperthermia (MFH). In MFH, superparamagnetic nanoparticles dissipate heat through Néelian and Brownian relaxation in the presence of an alternating magnetic field. The heating power of these particles is dependent on particle properties and treatment settings. A number of pre-clinical and clinical trials were performed to test the feasibility of this novel treatment modality. There are still issues yet to be solved for the successful transition of this technology from bench to bedside. These issues include the planning, execution, monitoring and optimization of treatment. The modeling and simulation play crucial roles in solving some of these issues. Thus, this review paper provides a basic understanding of the fundamental and rationales of hyperthermia and recent development in the modeling and simulation applied to depict the heat generation and transfer phenomena in the MFH.

Keywords: Bioheat transfer; Computational modeling; Magnetic fluid hyperthermia; Nanotechnology; Numerical methods; Optimization.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
a Typical graph of survival curve of a cell line which is heated at different temperatures for various durations, b typical graph of Arrhenius plot with a break point at around 43 °C
Fig. 2
Fig. 2
Different heat generation models in a magnetic nanoparticle in response to the alternative magnetic field. The short straight arrows represent the magnetic moment direction, the curved arrows represent the movement or change in direction, and the dash lines represent the domain boundaries in multi-domain particles
See this image and copyright information in PMC

References

    1. Steward BW, Wild CP. World cancer report 2014. Lyon: International Agency for Research on Cancer; 2014. - PubMed
    1. Habash RWY, Bansal R, Krewski D, Alhafid HT. Thermal therapy, part 1: an introduction to thermal therapy. Crit Rev Biomed Eng. 2006;34(6):459–489. doi: 10.1615/CritRevBiomedEng.v34.i6.20. - DOI - PubMed
    1. Habash RWY, Bansal R, Krewski D, Alhafid HT. Thermal therapy, part 2: hyperthermia techniques. Crit Rev Biomed Eng. 2006;34(6):491–542. doi: 10.1615/CritRevBiomedEng.v34.i6.30. - DOI - PubMed
    1. Habash RWY, Bansal R, Krewski D, Alhafid HT. Thermal therapy, part III: ablation techniques. Crit Rev Biomed Eng. 2007;35(1–2):37–121. doi: 10.1615/CritRevBiomedEng.v35.i1-2.20. - DOI - PubMed
    1. Barry SE. Challenges in the development of magnetic particles for therapeutic applications. Int J Hyperth. 2008;24(6):451–466. doi: 10.1080/02656730802093679. - DOI - PubMed

LinkOut - more resources