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Review
. 2017 Mar 23;7(1):358.
doi: 10.1038/s41598-017-00426-y.

PET Radiomics in NSCLC: state of the art and a proposal for harmonization of methodology

M Sollini  1 , L Cozzi  2   3 , L Antunovic  4 , A Chiti  2   4 , M Kirienko  2
Affiliations
Review

PET Radiomics in NSCLC: state of the art and a proposal for harmonization of methodology

M Sollini et al. Sci Rep. .

Abstract

Imaging with positron emission tomography (PET)/computed tomography (CT) is crucial in the management of cancer because of its value in tumor staging, response assessment, restaging, prognosis and treatment responsiveness prediction. In the last years, interest has grown in texture analysis which provides an "in-vivo" lesion characterization, and predictive information in several malignances including NSCLC; however several drawbacks and limitations affect these studies, especially because of lack of standardization in features calculation, definitions and methodology reporting. The present paper provides a comprehensive review of literature describing the state-of-the-art of FDG-PET/CT texture analysis in NSCLC, suggesting a proposal for harmonization of methodology.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Schematic representation of the process of selection of literature data included in the review.
Figure 2
Figure 2
Methodological approaches in image texture analysis (the most frequently evaluated PET features in lung cancer patients are reported as examples).
Figure 3
Figure 3
Example of tumor contouring using in (a) a threshold method at 50% of SUVmax and (b) a method based on an absolute SUV cut-off of 2.5. The ROI identified by using the absolute SUV cut-off of 2.5 is greater than that identified by the threshold method, as shown by axial (top), sagittal (right), and coronal (left) images (same slices).
See this image and copyright information in PMC

References

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