Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Nov 28:15:738-744.
doi: 10.17179/excli2016-346. eCollection 2016.

Colorectal cancer in Iran: Epidemiology and morphology trends

Hosein Rafiemanesh  1 , Reza Pakzad  2 , Mehdi Abedi  3 , Yones Kor  4 , Jalal Moludi  5 , Farhad Towhidi  6 , Behnam Reza Makhsosi  6 , Hamid Salehiniya  7
Affiliations

Colorectal cancer in Iran: Epidemiology and morphology trends

Hosein Rafiemanesh et al. EXCLI J. .

Abstract

Colorectal cancer is one of the most prevalent cancers in different countries, including Iran. No comprehensive study has been done in the country for colorectal cancer, but information on the incidence and trends is essential to planning. This study aimed to evaluate the occurrence and morphology of colorectal cancer and its trend in Iran. This study was conducted using data from the national cancer registry system in Iran from 2003-2008. We used joinpoint regression analysis for assessing incidence time trends and morphology change percentage. Of all cases of colorectal cancer, 61.83 % were colon cancer, 27.54 % rectal cancer, 7.46 % rectosigmoid cancer, and 3.10 anal cancer. The most common histological types with the frequencies of 80.85 % was related to adenocarcinoma, NOS. The Annual percentage changes (APC) in ASIR for colorectal cancer significantly increased in both men and women. APC in ASIR was 13.7 (CI: 10.5-17.1) in women and 16.4 (CI: 12.4-20.5) in men. APC of adenocarcinoma in villous adenoma showed significant declining trend (p<0.05), while APC of adenocarcinoma, NOS had a constant trend. The incidence of the cancer in recent years has increased in Iran because of changes in lifestyle and diet. Therefore, further studies are necessary to detect the cause of this cancer and perform preventive measures.

Keywords: Iran; colorectal cancer; epidemiology; morphology; trend.

PubMed Disclaimer

Figures

Table 1
Table 1. Number of cases, crude incidence rate and age-standardized incidence rates (per 100,000) of colorectal cancer by sex in Iran, 2003-2008
Table 2
Table 2. Number and percentage allocated of three common colorectal cancers morphology in Iran, 2003-2008
Table 3
Table 3. Joinpoint analyses of cancers percentage allocated to the morphology data for colorectal cancer in Iran, 2003-2008
Figure 1
Figure 1. Trends of the standardized incidence rate of colorectal cancer by sex in Iran, 2003-2008
See this image and copyright information in PMC

References

    1. Almasi Z, Rafiemanesh H, Salehiniya H. Epidemiology characteristics and trends of incidence and morphology of stomach cancer in Iran. Asian Pac J Cancer Prev. 2015;16:2757–2761. - PubMed
    1. Azizi F, Allahverdian S, Mirmiran P, Rahmani M, Mohammadi F. Dietary factors and body mass index in a group of Iranian adolescents: Tehran lipid and glucose study-2. Int J Vitam Nutr Res. 2001;71:123–127. - PubMed
    1. Boyle P, Langman J. ABC of colorectal cancer: Epidemiology. BMJ. 2000;321:805–808. - PMC - PubMed
    1. Boyle P, Leon ME. Epidemiology of colorectal cancer. Brit Med Bull. 2002;64:1–25. - PubMed
    1. Djazayery A, Pajooyan J. Food consumption patterns and nutritional problems in the Islamic Republic of Iran. Nutr Health. 2000;14:53–61. - PubMed

LinkOut - more resources