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Review
. 2017 Feb 1;7(2):173-186.
eCollection 2017.

Role of Notch signaling pathway in pancreatic cancer

Jiankun Gao  1 , Bo Long  2 , Zhiwei Wang  3
Affiliations
Review

Role of Notch signaling pathway in pancreatic cancer

Jiankun Gao et al. Am J Cancer Res. .

Abstract

Pancreatic cancer (PC) is one of the highly aggressive malignancies in the United States. It has been shown that multiple signaling pathways are involved in the pathogenesis of PC, such as JNK, PI3K/AKT, Rho GTPase, Hedgehog (Hh) and Skp2. In recent years, accumulated evidence has demonstrated that Notch signaling pathway plays critical roles in the development and progression of PC. Therefore, in this review we discuss the recent literature regarding the function and regulation of Notch in the pathogenesis of PC. Moreover, we describe that Notch signaling pathway could be down-regulated by its inhibitors or natural compounds, which could be a novel approach for the treatment of PC patients.

Keywords: Pancreatic cancer; cellular signaling; notch; target; therapy.

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Figures

Figure 1
Figure 1
Diagram of Notch signaling. Notch signaling pathway plays a pivotal role in the development and progression of PC via regulating its target genes. γ-secretase inhibitors and natural agents could be inhibitors of Notch pathway in PC cells.
Figure 2
Figure 2
Diagram of signaling pathways that control Notch expression in PC.
See this image and copyright information in PMC

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