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. 2017 Mar 8:4:18.
doi: 10.3389/fmed.2017.00018. eCollection 2017.

MAGE-A Antigens and Cancer Immunotherapy

Paul Zajac  1 , Elke Schultz-Thater  1 , Luigi Tornillo  2 , Charlotte Sadowski  1 , Emanuele Trella  1 , Chantal Mengus  1 , Giandomenica Iezzi  3 , Giulio C Spagnoli  1
Affiliations

MAGE-A Antigens and Cancer Immunotherapy

Paul Zajac et al. Front Med (Lausanne). .

Abstract

MAGE-A antigens are expressed in a variety of cancers of diverse histological origin and germinal cells. Due to their relatively high tumor specificity, they represent attractive targets for active specific and adoptive cancer immunotherapies. Here, we (i) review past and ongoing clinical studies targeting these antigens, (ii) analyze advantages and disadvantages of different therapeutic approaches, and (iii) discuss possible improvements in MAGE-A-specific immunotherapies.

Keywords: MAGE-A; adoptive immunotherapy; cancer immunotherapy; cancer–testis antigens; clinical trials.

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Figures

Figure 1
Figure 1
Heterogeneity of MAGE-A10 expression at the protein level. Melanoma tissues from a multi-tumor tissue microarray were stained with a MAGE-A10-specific reagent by standard techniques, as previously detailed (16). Antigen expression displays a high heterogeneity, regarding both percentages of antigen-positive tumor cells and staining intensity.
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