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. 2017 Mar 23;169(1):3-5.
doi: 10.1016/j.cell.2017.03.014.

Rejuvenation by Therapeutic Elimination of Senescent Cells

Paul Krimpenfort  1 , Anton Berns  2
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Free article

Rejuvenation by Therapeutic Elimination of Senescent Cells

Paul Krimpenfort et al. Cell. .
Free article

Abstract

In this issue of Cell, Baar et al. show how FOXO4 protects senescent cell viability by keeping p53 sequestered in nuclear bodies, preventing it from inducing apoptosis. Disrupting this interaction with an all-D amino acid peptide (FOXO4-DRI) restores p53's apoptotic role and ameliorates the consequences of senescence-associated loss of tissue homeostasis.

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